Chronic Colitis Non-specific colitis is a polyethiological disease. The etiology of colitis is sometimes unclear for both patient and doctor, and its treatment today is approached from the symptomatic aspects of the antiphlogistic approach. Thanks to the well-known bactericidal, viricidal and fungicidal properties of ozone, as well as its anti-inflammatory, circulatory and immune-stimulating effects, rectal ozone infusion, is a complementary therapy to the treatment of colitis.

In the process of absorption of active oxygen from the intestinal wall, it reacts with the inflammatory products of metabolism, eliminates the acidic and hypoxic environment and provides regeneration of the intestinal epithelium. Ozone activates phagocytes, pushes the button of humoral immunity. As a result, hemostasis is restored, microbial balance is normalized, and inflammation symptoms regress. An increase in blood pO2 normalizes intestinal motility.

Finally, rectal ozone insufflation has a general stimulating effect. This positive effect of ozone is particularly important for the psychic state of the patient with colitis. In active acute processes, it is recommended to start rectal ozone insufflation with a low volume of gas (100-150ml) and high ozone concentrations (10000 mcg/L), gradually increasing the volume of the gas mixture (up to a maximum of 900 ml) if the tolerance is good. together, the ozone concentration is reduced to 1000-3000 mcg/L. At the beginning of the treatment, insufflation is done daily, then 2-3 times a week, then the application frequency is reduced to once a week. If the patient begins to recover, the volume of gas delivered is reduced and low ozone concentrations are used. Recall that in the treatment of colitis, high ozone concentrations have an astringent effect and low ozone concentrations increase blood flow (H.H.Wolff, 1988).

For the stimulation of the immune system and the regeneration of the intestinal epithelium, it is recommended to apply minor autohemotherapy with 100 mcg of ozone twice a week, 5-6 injections are made for each treatment course. Antalya Ozone therapy can be used successfully in elderly patients if the cause of colitis is atherosclerotic arterial circulation disorder of the mesenteric artery, which is called “ischemic colitis”. In this case, the recommended gas mixture volume is 300-500 ml, the ozone concentration is 3000-5000 mcg/L, and it is applied every other day for 3-4 weeks. In colitic spastic forms, the ozone concentration used for insufflation is up to 10000 mcg/L and the gas mixture volume should be 300 ml. In such patients, intestinal washing (enema) with ozonated water is recommended before insufflation to increase the effectiveness of the treatment. In patients with chronic colitis, ozone therapy does not cause anybody resistance and prolongs the remission period (H. Knoch, W. Klug, 1990). To support the therapeutic effect achieved in these pathologies, ozone therapy is repeated 2-3 times a year. Unlike many antiseptics, ozone does not cause any damaging or corrosive effects.